The Arizona Cardinals are trying to improve to 5-0 for the first time since 1974 when they host the San Francisco 49ers on Sunday.
The 49ers are trying to snap a two-game skid. San Francisco has won three of the last four games in the series, but has some uncertainty at quarterback. 49ers QB Jimmy Garoppolo left last week's game with a calf injury and was replaced by rookie Trey Lance.
Garoppolo's status for Sunday hasn't been decided. Cardinals QB Kyler Murray is one of the early-season candidates for MVP after leading the franchise to an undefeated start.
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