East Naranja Drive is closed in both directions at Sawtooth Road, between North La Cañada Drive and North First Avenue, due to a water main break.
Crews are replacing a damaged 12-inch main and restoring the affected roadway, according to a news release from Oro Valley.
Repairs and restoration are expected to take about two weeks, the news release said.
Motorists should plan ahead and are encouraged to seek alternate routes while crews complete repairs.