Southbound Kinney Road is closed, just before West Ajo Highway, due to a three-vehicle crash.
The call came in at 11:37 a.m.
At least one person was transported to the hospital with life-threatening injuries.
Two others were transported with non-life-threatening injuries.
According to Pima County Sheriff's Department, the roadway will be closed for about two hours. The two turn lanes are also closed, PCSD said.
Drivers are asked to avoid the area.
