Update: Wednesday, April 16 8:04 p.m.
The road is now open.
The driver and a passenger of one of the vehicles were both transported to a hospital for their injuries.
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The intersection of South Old Spanish Trail and South Freeman Road is closed in all directions Wednesday afternoon due to a crash, according to the Pima County Sheriff's Department.
PCSD says the closure is due to a two-vehicle crash with serious injuries involved.
Drivers are asked to find an alternate route at this time while PCSD investigates the crash.