TUCSON, Ariz. (AP) - Sefo Liufau passed for three touchdowns and ran for another, helping No. 16 Colorado roll over Arizona 49-24 on Saturday night for the Buffaloes' first four-game winning streak in 14 years.
Colorado (8-2, 7-1 Pac-12, No. 12 CFP) had no trouble with the banged-up Wildcats, finding the offensive rhythm that had been missing the past two weeks.
Liufau was sharp after being banged up against UCLA, hitting 19 of 27 passes for 213 yards, including two touchdowns to Shay Fields. Liufau also ran for a 2-yard score.
Phillip Lindsay ran for 119 yards and three touchdowns, helping the Buffaloes to their best start since opening the 2001 season 8-2.
While Colorado is on course for the Pac-12 South title, Arizona (2-8, 0-7) is in the midst of its first seven-game losing streak since 2004.
The Wildcats outgained Colorado 417-388 in total yards but had three drives end with missed field goals by Josh Pollack.
Samajie Grant ran for 113 yards and two touchdowns for the Wildcats.
Colorado: The Buffaloes played the way they were supposed to against a downtrodden opponent to remain a game ahead of No. 13 Utah in the Pac-12 South.
Arizona: The Wildcats' defense was picked apart yet again and their offense was unable to capitalize on numerous chances. Arizona has two games left to avoid going winless in the Pac-12.
Colorado hosts Washington State next Saturday before its showdown against the Utes on Nov 26.
Arizona plays at Oregon State next Saturday, then closes out the season against rival Arizona State.