The North American Free Trade Agreement is still in negotiations, and President Donald Trump is suggesting to pull the plug on it.
Mexico is Arizona's top trading partner, and local business leaders say people from Mexico spend $7 million a day in Arizona.
On Tuesday, the Tucson Hispanic Chamber of Commerce, Arizona Chamber of Commerce and Industry and three chambers of commerce in Mexicali, Mexico signed memorandums enabling companies in both countries to expand cross border relationships and business.
"The Mexicali business community with open arms welcomed us," said Lea Márquez Peterson, the President, and CEO of Tucson Hispanic Chamber of Commerce.
She says Arizona's economy depends on a strong relationship with Mexico and Mexicali has many manufacturing companies looking for suppliers and vendors from the United States.
"A lot of the larger businesses are on the other side of the border so how do we, which are predominantly small businesses in southern Arizona, how do we patch in there to become suppliers or vendors or customers to some of their companies," she said.
She says the chambers of commerce will do workshops on how Mexico can do business in Arizona and how Arizona can do business in Mexico.